TAS-103 HC1

Name	TAS-103
Synonyms	TAS 103 CS-1287 TAS-103 BMS-247615 TAS-103 HC1 TAS-103 base TAS-103(salt) TA103(bms-247615) 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one
CAS	174634-08-3

Molecular Formula	C20H19N3O2
Molar Mass	333.38
Density	1.350±0.06 g/cm3(Predicted)
Melting Point	216-217 °C(Solv: ethanol (64-17-5))
Boling Point	589.5±50.0 °C(Predicted)
Solubility	10 mM in DMSO
pKa	7.88±0.20(Predicted)
Storage Condition	-20℃
In vitro study	TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC 50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC 50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.
In vivo study	TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.

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Product Name: TAS-103 Visit Supplier Webpage Request for quotation
CAS: 174634-08-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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TAS-103 HC1

TAS-103 HC1 Request for Quotation